特任教授，博士生导师
教育及工作经历：
吴中洋，理学博士，特任教授、博士生导师，免疫应答与免疫治疗全国重点实验室课题组负责人。入选2025国家海外高层次人才引进计划，于2026年8月正式加入中国科学技术大学生命科学与医学部。2021年于清华大学获得博士学位；2021年至2026年在美国波士顿儿童医院和哈佛医学院从事博士后研究，并为美国Broad研究所附属成员。以第一作者（含共同第一作者）在Cell、Cell Reports、STAR Protocols、Life Medicine等期刊发表研究论文，并作为共同作者在Immunity、Molecular Cell、Nature Chemical Biology、Nature Communications、Cell Research等期刊发表研究成果。荣获“Kenneth Rainin Innovations Symposium旅行奖“、“哈佛华人学者生命科学杰出研究奖”。
研究兴趣：
长期关注组织微环境如何指导免疫细胞的适应与命运决定，重点研究免疫细胞对环境变化的感知、细胞内多层级信息解码及髓系免疫细胞的功能重塑。主要研究方向包括：
1）组织微环境中的pH等生理信号如何被免疫细胞感知；
2）微环境信号如何被细胞内多层级调控体系解码；
3）组织微环境如何塑造髓系免疫细胞的分化、功能适应与炎症记忆，以及这些过程在感染、肿瘤和衰老中的作用。
实验室网页：
https://zhongyangwulab.github.io
ORCID iD：
0000-0002-3823-6014
代表性论文（*为共同第一作者）：
Zhongyang Wu, Krishnan Raghunathan, Zhe Zhong, Jay R. Thiagarajah, Xu Zhou. Protocol for immunoflueorescence detection and quatitative anaysis of pH-dependent transcriptional condensates. STAR Protocols, 2026, 7:104425
Shengyuan Wang,Zhongyang Wu, Zhe Zhong, Xu Zhou, Chongzhi Zang. Transcriptional condensates at super-enhancers mediate pH-dependent transcriptional control in innate immunity,bioXiv, 2025, 2025.10.29.685293
Zhongyang Wu*, Scott D. Pope*, Nasiha S. Ahmed, Diana L. Leung, Yu Hong, Stephanie Hajjar, Cathleen Krabak, Zhe Zhong, Krishnan Raghunathan, Qiuyu Yue, Diya M. Anand, Elizabeth B. Kopp, Daniel Okin, Weiyi Ma, Ivan Zanoni, Jonathan C. Kagan, Jay R. Thiagarajah, Diana C. Hargreaves, Ruslan Medzhitov, Xu Zhou. Regulation of inflammatory responses by pH-dependent transcriptional condensates.Cell, 2025, 188:1-21. Highted by Nature Reviews Immunology, Nature Cell Biology
Marco Di Gioia, Valentina Poli, Piao J Tan, Roberto Spreafico, Anne Chu, Alex G Cuenca,Zhongyang Wu, Mehdi Benamar, Laura Pandolfi, Federica Meloni, Fatemeh Askarian, Jason Hsiao, Elizaveata Borroum, Victor Nizet, Philip LSM Gordts, Joseph L Witztum, Talal A Chatila, Janet Chou, Xu Zhou, James R Springstead, Ivan Zanoni. Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids fosters a lethal inflammatory response to infections.Immunity, 2025, 58:1-18.
Xi Chen, Krishanan Raghunathan, Bin Bao, Elsy Ngwa, Andrew Kwong,Zhongyang Wu, Stephen Babcock, Clara Baek, George Ye, Anoohya Muppirala, Qianni Peng, Michael Rutlin, Mantu Bhaumik, Daping Yang, Daniel Kotlarz, Unmesh Jadhav, Meenakshi Rao, Eranthie Weerapana, Xu Zhou, Jose Ordovas-Montanes, Scott B Snapper, Jay R Thiagarajah.A niche-dependent redox rheostat regulates epithelial stem cell fate in the distal colon,Nature Communications,2025, 16:11713
Zhongyang Wu, Xu Zhou. Hematopoietic anomalies fuels multiple sclerosis.Life Medicine, 2022, 1:52-54
Wen Shao, Xianju Bi, Yixuan Pan, Boyang Gao, Jun Wu, Yafei Yin, Zhimin Liu, Mengyuan Peng, Wenhao Zhang, Xu Jiang, Wenlin Ren, Yanhui Xu,Zhongyang Wu, Kaili Wang, Ge Zhan, J Yuyang Lu, Xue Han, Tong Li, Jianlong Wang, Guohong Li, Haiteng Deng, Bing Li, Xiaohua Shen. Phase separation of RNA-binding protein promotes polymerase binding and transcription.Nature Chemical Biology, 2022, 18, 70-80.
J Yuyang Lu, Lei Chang, Tong Li, Ting Wang, Yafei Yin, Ge Zhan, Xue Han, Ke Zhang, Yibing Tao, Michelle Percharde, Liang Wang, Qi Peng, Pixi Yan, Hui Zhang, Xianju Bi, Wen Shao, Yantao Hong,Zhongyang Wu, Runze Ma, Peizhe Wang, Wenzhi Li, Jing Zhang, Zai Chang, Yingping Hou, Bing Zhu, Miguel Ramalho-Santos, Pilong Li, Wei Xie, Jie Na, Yujie Sun, Xiaohua Shen.Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome.Cell Research, 2021, 31:613-630.
Hui Zhang*, Zhongyang Wu*, J.Yuyang Lu*, Bo Huang, Hongwei Zhou, Wei Xie, Jianlong Wang, and Xiaohua Shen. DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.Cell Reports. 2020, 30, 81-97 e87.Recommended by F1000Prime for significance
J,Yuyang Lu, Wen Shao, Lei Chang, Yafei Yin, Tong Li, Hui Zhang, Yantao Hong, Michelle Percharde, Lerui Guo,Zhongyang Wu, Lichao Liu, Wei Liu, Pixi Yan, Miguel Ramalho-santos, Yujie Sun, Xiaohua Shen. Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation.Cell Reports, 2020, 30:3296-3311.
Xianju Bi, Yanhui Xu, Tong Li, Xinmin Li, Wenzhi Li, Wen Shao, Kaili Wang, Ge Zhan,Zhongyang Wu, Wei Liu, Yafei Yin, J. Yuyang Lu, Liang Wang, Jicheng Zhao, Jiawei Wu, Jie Na, Guohong Li, Pilong Li, Xiaohua Shen. RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control.Molecular Cell, 2019, 75, 102-116
招生与招聘：
课题组长期招收对组织微环境、固有免疫、炎症反应、表观遗传调控和生物大分子凝聚体感兴趣的本科生、硕士生、博士生及博士后。欢迎具有免疫学、分子细胞生物学、生物信息学或生物物理学背景的同学联系。