余家力，特任研究员。2025年12月加入中国科学技术大学生命科学与医学部、免疫应答与免疫治疗全国重点实验室。近五年围绕肿瘤免疫耐受和免疫治疗耐药机制取得一系列成果；以第一作者(含共同)在Cell、Nature Medicine、Nature Communications、Cell Reports等国际高水平杂志发表论文；以参与作者在Science、Nature、Cancer Cell、Nature Immunology等国际高水平杂志发表论文.
主要研究方向：
聚焦肿瘤免疫方向，开展肿瘤免疫耐受及免疫治疗耐药机制研究，旨在开发创新型肿瘤免疫治疗策略
● 肿瘤免疫耐受与免疫治疗
● 免疫衰老与抗肿瘤免疫
● 免疫基因组学
教育及工作经历
● 2025-至今 中国科学技术大学，特任研究员
● 2023-2025密歇根大学，ResearchInvestigator(初期教职)
● 2018-2023密歇根大学，博士后
● 2011-2017中国科学技术大学，博士
● 2007-2011中国科学技术大学，学士
代表性论文
1. Zhou J, Tison K, Zhou H, Bai L, Acharyya RK, McEachern D, Metwally H, Wang Y, Pitter M, Choi JE, Vatan L, Liao P, Yu J, Lin H, Jiang L, Wei S, Gao X, Grove S, Parolia A, Cieslik M, Kryczek I, Green MD, Lin JX, Chinnaiyan AM, Leonard WJ, Wang S, Zou W. STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity. Nature 2025, PMID: 40369063.
2. Yan Y*, Yu J*, Wang W, Xu Y, Tison K, Xiao R, Grove S, Wei S, Vatan L, Wicha M, Kryczek I, and Zou W (*Co-first author). Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion. Nat Commun 2025, PMID:40341398.
3. Bao Y, Cruz G, Zhang Y, Qiao Y, Mannan R, Hu J, Yang F, Gondal M, Shahine M, Kang S, Mahapatra S, Chu A, Choi JE, Yu J, Lin H, Miner SJ, Robinson DR, Wu YM, Zheng Y, Cao X, Su F, Wang R, Hosseini N, Cieslik M, Kryczek I, Vaishampayan U, Zou W, Chinnaiyan AM. The UBA1-STUB1 axis mediates cancer immune escape and resistance to checkpoint blockade. Cancer Discov 2024. PMID: 39540840.
4. Lin H, Tison K, Du Y, Kirchhoff P, Kim C, Wang W, Yang H, Pitter M, Yu J, Liao P, Zhou J, Vatan L, Grove S, Wei S, Vigil T, Shah YM, Mortensen R, Kryczek I, Garmire L, Sivaccumar JP, Ramesh AK, Zhang N, An Z, Wang S, Zou W. Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance. Cancer Cell S1535-6108(24)00398-2, 2024. PMID: 39515327.
5. Yu J*, Yan Y*, Li S, Xu Y, Parolia A, Rizvi S, Wang W, Zhai Y, Xiao R, Li X, Liao P, Zhou J, Okla K, Lin H, Lin X, Grove S, Wei S, Vatan L, Hu J, Szumilo J, Kotarski J, Freeman ZT, Skala S, Wicha M, Cho KR, Chinnaiyan AM, Schon S, Wen F, Kryczek I, Wang S, Chen L, Zou W (*Co-first author): Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance. Cell S0092-8674(24)00652-4, 2024. PMID: 38968937.
6. Choi JE, Qiao Y, Kryczek I, Yu J, Gurkan J, Bao Y, Gondal M, Tien JC, Maj T, Yazdani S, Parolia A, Xia H, Zhou J, Wei S, Grove S, Vatan L, Lin H, Li G, Zheng Y, Zhang Y, Cao X, Su F, Wang R, He T, Cieslik M, Green MD, Zou W, Chinnaiyan AM: PIKfyve, expressed by CD11c-positive cells, controls tumor immunity. Nat Commun 15(1):5487, 2024. PMID: 38942798
7. Lo BC, Kryczek I, Yu J, Vatan L, Caruso R, Matsumoto M, Sato Y, Shaw MH, Inohara N, Xie Y, Lei YL, Zou W, Núñez G: Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade-associated colitis via Fcγ receptors. Science 383(6678):62-70, 2024. PMID: 38175892
8. Bao Y, Qiao Y, Choi JE, Zhang Y, Mannan R, Cheng C, He T, Zheng Y, Yu J, Gondal M, Cruz G, Grove S, Cao X, Su F, Wang R, Chang Y, Kryczek I, Cieslik M, Green MD, Zou W, Chinnaiyan AM: Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy. Proc Natl Acad Sci U S A. 120(49):e2314416120, 2023. PMID: 38011559
9. Li S*, Yu J*, Huber A, Kryczek I, Wang Z, Jiang L, Li X, Du W, Li G, Wei S, Vatan L, Szeliga W, Chinnaiyan AM, Green MD, Cieslik M, Zou W (*Co-first author): Metabolism drives macrophage heterogeneity in the tumor microenvironment. Cell Rep 39(1):110609, 2022. PMID: 35385733
10. Qiao Y, Choi JE, Tien JC, Simko SA, Rajendiran T, Vo JN, Delekta AD, Wang L, Xiao L, Hodge NB, Desai P, Mendoza S, Juckette K, Xu A, Soni T, Su F, Wang R, Cao X, Yu J, Kryczek I, Wang XM, Wang X, Siddiqui J, Wang Z, Bernard A, Fernandez-Salas E, Navone NM, Ellison SJ, Ding K, Eskelinen EL, Heath EI, Klionsky DJ, Zou W, Chinnaiyan AM: Autophagy Inhibition by Targeting PIKfyve Potentiates Response to Immune Checkpoint Blockade in Prostate Cancer. Nat Cancer 2:978-993, 2021. PMID: 34738088
11. Lin H, Kryczek I, Li S, Green MD, Ali A, Hamasha R, Wei S, Vatan L, Szeliga W, Grove S, Li X, Li J, Wang W, Yan Y, Choi JE, Li G, Bian Y, Xu Y, Zhou J, Yu J, Xia H, Wang W, Alva A, Chinnaiyan AM, Cieslik M, Zou W: Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance. Cancer Cell 39(4):480-493, 2021. PMID: 33513345
12. Zhou J, Kryczek I, Li S, Li X, Aguilar A, Wei S, Grove S, Vatan L, Yu J, Yan Y, Liao P, Lin H, Li J, Li G, Du W, Wang W, Lang X, Wang W, Wang S, Zou W: The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity. Nat Immunol 22(4):460-470, 2021. PMID: 33767425
13.Yu J*, Green MD*, Li S, Sun Y, Journey SN, Choi JE, Rizvi SM, Qin A, Waninger JJ, Lang X, Chopra Z, El Naqa I, Zhou J, Bian Y, Jiang L, Tezel A, Skvarce J, Achar RK, Sitto M, Rosen BS, Su F, Narayanan SP, Cao X, Wei S, Szeliga W, Vatan L, Mayo C, Morgan MA, Schonewolf CA, Cuneo K, Kryczek I, Ma VT, Lao CD, Lawrence TS, Ramnath N, Wen F, Chinnaiyan AM, Cieslik M, Alva A, Zou W (*Co-first author): Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. Nat Med 27(1):152-164, 2021. PMID: 33398162
14.Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, Nwosu ZC, Zhang L, Czerwonka A, Pawłowska A, Xia H, Li J, Liao P, Yu J, Vatan L, Szeliga W, Wei S, Grove S, Liu JR, McLean K, Cieslik M, Chinnaiyan AM, Zgodziński W, Wallner G, Wertel I, Okła K, Kryczek I, Lyssiotis CA, Zou W: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature 585(7824):277-282, 2020. PMID: 32879489
15.Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, Saripalli AL, Kryczek I, Wei S, Szeliga W, Vatan L, Stone EM, Georgiou G, Cieslik M, Wahl DR, Morgan MA, Chinnaiyan AM, Lawrence TS, Zou W: Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discov 9(12):1673-1685, 2019. PMID: 31554642
16.Yu J, Chen Y, Wu Y, Ye L, Lian Z, Wei H, Sun R, Tian Z: The differential organogenesis and functionality of two liver-draining lymph nodes in mice. J Autoimmun 84:109-121, 2017. PMID: 28886898
17.Zheng M, Yu J, Tian Z: Characterization of the liver-draining lymph nodes in mice and their role in mounting regional immunity to HBV. Cell Mol Immunol 10(2):143-50, 2013. PMID: 23376862
联系方式
● 邮箱：yjlyu@ustc.edu.cn
招生招聘
本课题组长期招聘免疫学、细胞生物学、分子生物学、遗传学和生物信息学等相关背景的博士后及特任副研究员，同时诚挚欢迎对本课题组感兴趣的研究生和本科生加入。