朱乐乐，特任教授，博士生导师，2023年加入中国科学技术大学生命科学与医学部，2015年至2023年先后在德州大学MD安德森癌症中心任博士后和讲师，休斯顿卫理公会研究所任研究科学家。主要围绕肿瘤与感染性疾病的免疫调控开展研究，旨在揭示宏观与微观环境下T细胞免疫感知与应答调控的机制，解析肿瘤免疫编辑的作用机理，通过将基础发现转化为创新的免疫疗法及药物，助力临床应用，研究成果发表于Immunity，Nature Immunology，Nature Cell Biology，Journal of Experimental Medicine，Nature Communications，Blood和Science Advances等国际知名期刊，作为主要完成人获得教育部2020年度高等学校科学研究优秀成果奖（科学技术）自然科学一等奖。
主要研究兴趣：
1.T淋巴细胞分化与活化的机制与肿瘤免疫应答。
2.肿瘤免疫编辑的作用机制与肿瘤免疫治疗策略。
3.肿瘤免疫治疗新药物与疗法的研发。
主要学术论文：
1. Y.C. Li, L.L. Zhu, C.J. Ko, J.Y. Yang, H.J. Wang, G. Manyam, J. Wang, X.H. Cheng, S.L. Zhao, Z.L. Jie (2023), TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses. The Journal of Experimental Medicine220(8):e20221483.
2. L.L. Zhu#, X.F. Zhou, M. Gu, J. Kim, Y.C. Li, C-J Ko, X.P. Xie, T.X. Gao, X.H. Cheng, and S- C Sun# (2022). Dapl1 suppresses CD8 T cell responses by controlling NFATc2 activation. Nature Cell Biology24(7):1165-1176(#co-corresponding author).
3. M. Gu, X. Zhou, J. H. Sohn, L.L. Zhu, Z. Jie, J. Y. Yang, X. Zheng, X. Xie, J. Yang, Y. Shi, H. D. Brightbill, J. B. Kim, J. Wang, X. Cheng and S. C. Sun (2021). NF-kappaB-inducing kinase maintains T cell metabolic fitness in antitumor immunity. Nature Immunology22(2): 193-204.
4. Li, Y., X. Xie, Z. Jie, L.L. Zhu, J. Y. Yang, C. J. Ko, T. Gao, A. Jain, S. Y. Jung, N. Baran, M. Y. Konopleva, X. Cheng and S. C. Sun (2021). DYRK1a mediates BAFF-induced noncanonical NF-kappaB activation to promote autoimmunity and B-cell leukemogenesis. Blood138(23): 2360-2371.
5. Xie, X., L.L. Zhu, Z. Jie, Y. Li, M. Gu, X. Zhou, H. Wang, J. H. Chang, C. J. Ko, X. Cheng and S. C. Sun (2021). TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells. Cellular & Molecular Immunology18(9): 2262-2274.
6. L.L. Zhu, Y. Li, X. Xie, X. Zhou, M. Gu, Z. Jie, C. J. Ko, T. Gao, B. E. Hernandez, X. Cheng and S. C. Sun (2019). TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis. Nature Cell Biology21(12): 1604-1614.
7. L.L. Zhu, X. Xie, L. Zhang, H. Wang, Z. Jie, X. Zhou, J. Shi, S. Zhao, B. Zhang, X. Cheng and S. C. Sun (2018). TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nature Communications9(1): 2812.
8. L.L. Zhu, T. M. Luo, X. Xu, Y. H. Guo, X. Q. Zhao, T. T. Wang, B. Tang, Y. Y. Jiang, J. F. Xu, X. Lin and X. M. Jia (2016). E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity. Journal of Experimental Medicine213(8): 1555-1570.
9. X.M. Jia*, B. Tang*, L.L. Zhu*, Y. H. Liu, X. Q. Zhao, S. Gorjestani, Y. M. Hsu, L. Yang, J. H. Guan, G. T. Xu and X. Lin (2014). CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity. Journal of Experimental Medicine211(11): 2307-2321.(*co-first author).
10. L.L. Zhu, X. Q. Zhao, C. Jiang, Y. You, X. P. Chen, Y. Y. Jiang, X. M. Jia and X. Lin (2013). C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection.Immunity39(2): 324-334.
招生招聘：
1．实验室常年诚挚招聘有生物信息学、免疫学、细胞生物学、肿瘤学等相关研究背景的博士后和副研究员。
2．实验室常年热忱欢迎对本课题组研究方向感兴趣的本科生、研究生前来交流和攻读博士学位或进行本科毕业论文研究。
联系方式：lzhu6@ustc.edu.cn