朱乐乐，特任教授，博士生导师，国家海外高层次青年人才项目入选者，2023年2月加入中国科学技术大学生命科学与医学部。2014年毕业于同济大学获得博士学位；2015年至2023年先后在德州大学MD安德森癌症中心任博士后和讲师，休斯顿卫理公会研究所任研究科学家。主要研究方向围绕抗感染和肿瘤的免疫应答及调控机制，取得了一系列突出的学术成果，研究成果分别以第一作者或通讯作者发表在Immunity，Nature Cell Biology（2篇），Nature Communications，Journal of Experimental Medicine（2篇）等国际知名期刊，曾获MD安德森癌症中心Center for Inflammation and Cancer Scholar Award、A. Lavoy Moore Endowment Fund for Lung Cancer Research；作为主要完成人获得教育部2020年度高等学校科学研究优秀成果奖（科学技术）自然科学一等奖。
主要研究兴趣与方向：
1. T细胞的调控与肿瘤、感染和自身免疫性疾病；
2. 肿瘤的免疫逃逸与耐受的作用机制；
3. 免疫治疗肿瘤和自身免疫性疾病靶向药物的研发。
主要学术论文（时间排序）：
(1) L.L. Zhu#, X.F. Zhou, M. Gu, J. Kim, Y.C. Li, C-J Ko, X.P. Xie, T.X. Gao, X.H. Cheng, and S. C. Sun# (2022). Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer. Nat Cell Biol，24(7):1165-1176. (#co-corresponding author).
(2) Gao, T., T. Liu, C. J. Ko, L. Zhang, D. Joo, X. Xie, L.L. Zhu, Y. Li, X. Cheng and S. C. Sun (2022). Myeloid cell TBK1 restricts inflammatory responses. Proc Natl Acad Sci U S A 119(4).
(3) M.Gu, X. Zhou, J. H. Sohn, L.L. Zhu, Z. Jie, J. Y. Yang, X. Zheng, X. Xie, J. Yang, Y. Shi, H. D. Brightbill, J. B. Kim, J. Wang, X. Cheng and S. C. Sun (2021). NF-kappaB-inducing kinase maintains T cell metabolic fitness in antitumor immunity. Nat Immunol 22(2): 193-204.
(4) Li, Y., X. Xie, Z. Jie, L.L. Zhu, J. Y. Yang, C. J. Ko, T. Gao, A. Jain, S. Y. Jung, N. Baran, M. Y. Konopleva, X. Cheng and S. C. Sun (2021). DYRK1a mediates BAFF-induced noncanonical NF-kappaB activation to promote autoimmunity and B-cell leukemogenesis. Blood 138(23): 2360-2371.
(5) Xie, X., L.L. Zhu, Z. Jie, Y. Li, M. Gu, X. Zhou, H. Wang, J. H. Chang, C. J. Ko, X. Cheng and S. C. Sun (2021). TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells. Cell Mol Immunol 18(9): 2262-2274.
(6) Ko, C. J., L. Zhang, Z. Jie, L.L. Zhu, X. Zhou, X. Xie, T. Gao, J. Y. Yang, X. Cheng and S. C. Sun (2021). The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses. EMBO J 40(2): e104532.
(7) Zhang, L., C. J. Ko, Y. Li, Z. Jie, L.L. Zhu, X. Zhou, X. Xie, T. Gao, T. Liu, X. Cheng and S. C. Sun (2021). Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination. Cell Rep 37(4): 109904.
(8) Z.Jie, C. J. Ko, H. Wang, X. Xie, Y. Li, M. Gu, L.L. Zhu, J. Y. Yang, T. Gao, W. Ru, S. J. Tang, X. Cheng and S. C. Sun (2021). Microglia promote autoimmune inflammation via the noncanonical NF-kappaB pathway. Sci Adv 7(36): eabh0609.
(9) L.L. Zhu, Y. Li, X. Xie, X. Zhou, M. Gu, Z. Jie, C. J. Ko, T. Gao, B. E. Hernandez, X. Cheng and S. C. Sun (2019). TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis. Nat Cell Biol 21(12): 1604-1614.
(10) L.L. Zhu, X. Xie, L. Zhang, H. Wang, Z. Jie, X. Zhou, J. Shi, S. Zhao, B. Zhang, X. Cheng and S. C. Sun (2018). TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun 9(1): 2812.
(11) Z. Jie, J. Y. Yang, M. Gu, H. Wang, X. Xie, Y. Li, T. Liu, L.L. Zhu, J. Shi, L. Zhang, X. Zhou, D. Joo, H. D. Brightbill, Y. Cong, D. Lin, X. Cheng and S. C. Sun (2018). NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nat Immunol 19(11): 1224-1235.
(12) L.L. Zhu, T. M. Luo, X. Xu, Y. H. Guo, X. Q. Zhao, T. T. Wang, B. Tang, Y. Y. Jiang, J. F. Xu, X. Lin and X. M. Jia (2016). E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity. J Exp Med 213(8): 1555-1570.
(13) X.M. Jia*, B. Tang*, L.L. Zhu*, Y. H. Liu, X. Q. Zhao, S. Gorjestani, Y. M. Hsu, L. Yang, J. H. Guan, G. T. Xu and X. Lin (2014). CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity. J Exp Med 211(11): 2307-2321. (*co-first author).
(14) L.L. Zhu, X. Q. Zhao, C. Jiang, Y. You, X. P. Chen, Y. Y. Jiang, X. M. Jia and X. Lin (2013). C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity 39(2): 324-334.
招生招聘：
1．实验室常年诚挚招聘有生物信息学、免疫学、细胞生物学、肿瘤学等相关研究背景的博士后和副研究员。
2．实验室常年热忱欢迎对本课题组研究方向感兴趣的本科生、研究生前来交流和攻读博士学位或进行本科毕业论文研究。
联系方式：lzhu6@ustc.edu.cn