教授,博士生导师。国家杰出青年基金获得者(2020年),国家青年高层次海外人才计划入选者(2015年)。2005年于中国科学技术大学获得学士学位;2010年于中国科学技术大学获得博士学位;2011年1月起先后于圣路易斯华盛顿大学生物医学工程系、佐治亚理工学院生物医学工程系及芝加哥大学James Franck研究所从事博士后研究。2015年9月入职中国科学技术大学生命科学学院任教,主持或参与基金委国际合作与交流项目、重大研究计划集成项目、重点项目、面上项目;科技部重点研发“纳米专项”、科技部重点研发“变革性项目”;中国科学院基础与交叉前沿科研先导专项等。多年来一直从事纳米材料在癌症治疗及其体内生物界面的研究,在Nat. Nanotech.、Nat. Mater.、Nat. Biomed. Eng.、Nat. Commun.国际学术期刊发表研究论文100余篇。
研究方向:生物医用高分子、核酸药物、显微活体成像
代表性论文(#为第一作者,*为通讯作者):
[1] Q. Wang#, Q. R Liang#, J.X. Dou, H. Zhou, C. C. Zeng, H. M. Pan, Y. Q. Shen, Q. L., Y. Liu, D. T. Leong*, W. Jiang*, Y. C. Wang*. Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumors. Nature Nanotechnology, 2023, doi.org/10.1038/s41565-023-01498-w.
[2] M. I. Setyawati #*, Q. Wang #, N. Ni, J. K. Tee, K. Ariga, P. C. Ke, H. K. Ho, Y. C. Wang* & D. T. Leong*. Engineering tumoral vascular leakiness with gold nanoparticles. Nature Communications, 2023, 14:4269.
[3] M. Li #, H. Zhou #, N. Wu, W. Deng, W. Dong, X. Sun, Z. Tian, Y. C. Wang*. Pathogen Recognition-Driven Dendritic Cell-Specific Gene Silencing and Editing. Nano Letters. 2023, 23, 2733-2742.
[4] G. Zhang #, Q. Wang #, W. Tao #, W. Jiang, E. Eran, Y. C. Wang* & S. Zhu *. Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. Nature Biomedical Engineering. 2022, 6, 867-881.
[5] W. Jiang#, Z. Shen#, Z. Guo#, Q. Wang, Q. Li, J. Hu, * and Y. C. Wang*. Overcoming oxygen heterogeneity of tumor microenvironments to boost cancer immunotherapy by oxygen-switchable ROS/RNS nanogenerators, Nano Today 2023, 48,101696
[6] W. Jiang,# W. Dong,# M. Li,# Z. Guo, Q. Wang, Y. Liu, Y. Bi, H. Zhou, Y. C. Wang*. Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy. ACS Nano 2022, 16, 3881-3894.
[7] Y. Wu#, Y. Shen #, N. Wu #, X. Zhang #, S. Chen, C. Yang, J. Zhou, Y. Wu, D. Chen, L. Wang, Y. Wang, J. Xu, K. Liu, C. Wang, H. Zhang *, N. Xia *, S. Chiu *, Y. C. Wang *, Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates, Cell Research 2022, 32: 949-952.
[8] M. Li#, D. Xie#, X. F. Tang#, C. Yang, Y. Q. Shen, H. Zhou, W. X. Deng, J. W. Liu, S. B . Cai, L. Bai*, Y. C. Wang*, Phototherapy Facilitates Tumor Recruitment and Activation of Natural Killer T cells for Potent Cancer Immunotherapy. Nano Letters 2021, 21, 6304-6313
[9] Y. H. Bi#, W. X. Duan#, J. Chen#, T. You,* S. Y. Li, W. Jiang, M. Li, G. Wang, X. Y. Pan, J. Wu, D. Liu, J. Li,* and Y. C. Wang*,Neutrophil Decoys with Anti-Inflammatory and AntiOxidative Properties Reduce Secondary Spinal Cord Injury and Improve Neurological Functional Recovery. Advanced Functional Materials. 2021, 2102912
[10] M. Li,# S. Li,# H. Zhou, X Tang, Y. Wu, W. Jiang, Z. Tian, X. Zhou, X. Yang, Y. C. Wang.* Chemotaxis-Driven Delivery of Nano-pathogenoids for Complete Eradication of Tumors Postphototherapy. Nature Communications, 2020, 11, 1126