研究方向：
肠道作为人体最大的粘膜免疫器官，聚集了远超过人体细胞数目的微生物和全身一半以上的免疫细胞。我们每日摄入的食物以及肠道微生物通过什么物质塑造了肠道免疫微环境并影响人体健康和疾病是我们实验室关注的核心科学问题。近年来，我们实验室的工作集中在如下三个部分:
1.解析了肠道特异的先天免疫识别受体 NLRP6 感知肠道微生物并维持免疫稳态的新机制。鉴定 NLRP6 为首个识别 dsRNA 的 Nod 样受体(Science 2015)，并发现 NLRP6 依次和 dsRNA 形成液液相分离并和 Asc 组装炎症小体的关键位点(Cell 2021;PNAS 2024)。
2.发现 NLRP6 的效应分子 GSDMD 响应食物抗原刺激诱导免疫耐受的机制。十二指肠上皮细胞中食物抗原诱导 GSDMD 剪切入核上调 MHCII 诱导 Tr1 介导免疫耐受(Cell 2023)。缺乏蛋白质抗原的食物导致肠道微生物紊乱及抑郁样行为(Cell Reports 2024)。3.鉴定了调控肠炎和肠癌发病的微生物来源代谢物如梭状芽胞杆菌产生的 DCA(Immunity 2024)，厌氧消化链球菌分泌的 IDA(Nat Cell Bio 2024)，及食物来源的 Vitamin B5(Cell Reports 2022)。并开发不破坏肠道微生物的抗生素递送新方法 (Nat BME 2022)。
个人简介：
基础医学院执行院长，生命科学与医学部副部长。国家杰青。曾获中组部创新人才计划，基金委优青、MIT 35 Innovators under 35 China，求是杰出青年学者奖，中源协和创新突破奖等。研究方向为肠道微生物的免疫识别和免疫调控，以及微生物及免疫新疗法。发表文章70余篇，近5年以通讯作者在Cell（2023，2021），Immunity（2024），Nature Biomedical Engineering（2022），Cell Research (2023)，PNAS (2024，2021)，Science Advance (2023)，Cell Reports (2024，2022)，Nature Reviews Gastroenterology & Hepatology（2022）等杂志发表研究和综述论文。总引用8000余次，H index 39。Nature、Cell、Immunity、Lancet、PNAS、Gut等杂志审稿人。以第一发明人申请国家发明专利15项，PCT专利3项，获批发明专利6项，3个项目已获得批件进入研究者发起的临床试验阶段。
实验室网页：http://zhulab.ustc.edu.cn/
联系方式：zhushu@ustc.edu.cn
电话：0551-63600317
OCRID ID: 0000-0002-8163-0869
教育和研究经历：
2002-2006年，中国科学技术大学生命科学学院，获学士学位
2006-2012年，上海生命科学研究院健康科学研究所，获细胞生物学博士学位
2012-2017年，美国耶鲁大学医学院免疫学系，博士后
2017年 至今，中国科学技术大学生命科学与医学部，教授博导
获奖情况：
2006年 郭沫若奖学金
2011年 中科院院长优秀奖
2011年 强生亚洲优秀研究生论文奖
2012年 中科院院长特别奖
2012年 吴瑞奖学金
2012年 中科院百篇优博论文
2014年 Helen-Hay Whitney-HHMI Fellowship
2017年 中组部创新人才计划
2018年 MIT Technology Review 35 Innovators Under 35（MIT TR35 China）
2018年 求是杰出青年学者
2018年 基金委优青
2022年 中源协和创新突破奖
2023年 基金委杰青
发表论文：(*第一作者，#通迅作者)
2024
70. Cong J*, Liu P*, Han Z*, Ying W, Li C, Yang J, Song X, Dai L, Sun L, Kasper D, Pan W#, Zhu S#. Bile acids modified by the microbiota suppress gut anti-tumor immune responses. Immunity. 2024 Mar 6:S1074-7613(24)00090-6. doi: 10.1016/j.immuni.2024.02.014.
69. Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell RA, Liu Z#, Li M#, Pan W#, Zhu S#. DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Nature Communications. 2024. In Press
68. Hu J*, He K*, Yang Y*, Huang C, Dou Y, Wang H, Zhang G, Wang J, Niu C, Bi G, Zhang L#, Zhu S#. Amino-acid formula induces microbiota dysbiosis and contributes to depressive-like behavior. Cell Reports. 2024 Feb 26;43(3):113817.doi: 10.1016/j.celrep.2024.113817. (IF=10.0)
67. Li R*, Zan Y*, Wang D, Chen X, Wang A, Tan H, Zhang G, Ding S, Shen C#, Wu H#, Zhu S#. A mouse model to distinguish NLRP6-mediated inflammasome-dependent and independent functions. PNAS. 2024 Feb 6;121(6):e2321419121. doi: 10.1073/pnas.2321419121. (IF=11.1)
66. W Cui, M Guo, D Liu, Y Zhang, J Cong, Z Han, Y Yang, J Liu, C Liang, S Shi, P Xiao, C Yang, H Huang, X Fu, Y Xu, L Du, C Yin, Y Zhang, J Sun, R Chai#, W Gu#, S Zhu#, B Chu#. Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition. Nature Cell Biology. 26, 124–137 (2024). (IF=28.2)
2023
65. K He*, T Wan*, D Wang*, J Hu*, T Zhou, W Tao, Z Wei, Q Lu, R Zhou, Z Tian, R Flavell#, and S Zhu#. Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. Cell. 2023 Jun 9;S0092-8674(23)00577-9. doi: 10.1016/j.cell.2023.05.027. (IF=66.9)
Comment in:
Trends in Immunology. 2023 Aug;44(8):571-573. doi: 10.1016/j.it.2023.06.006. Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens.
Cell Research. 2023 Dec;33(12):896-897. doi: 10.1038/s41422-023-00856-6. Cleaving an epithelial path to food tolerance.
Gastroenterology. doi:10.1053/j.gastro.2023.08.024. Tolerance to Dietary Antigens in the Upper Intestine Through Chopping of Gasdermin D.
Allergy. doi: 10.1111/all.16076. Insights in intestinal immune tolerance: The role of the cleavage form of gasdermin D.
64. T Wan*, Y Wang*, K He*, S Zhu#. Microbial sensing in the intestine. Protein & Cell, pwad028, 2023. doi.org/10.1093/procel/pwad028. (IF=15.3)
61. X Wang*, C Chen*, H Sun*, K Mao*, J Yao, W Zhang, M Zhan, H-B Li, Z Zhang#, S Zhu#, L Lu#. m6A mRNA modification potentiates Th17 functions to inflame autoimmunity. Sci. China Life Sci. (2023). https://doi.org/10.1007/s11427-022-2323-4. (IF=10.4)
60. Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, Liu X, Kim Y, Lee HS, Kawai Y, Nagasaki M, Umeno J, Tokunaga K, Kinouchi Y, Masamune A, Shi W, Shen C, Guo Z, Yuan K; FinnGen; International Inflammatory Bowel Disease Genetics Consortium; Chinese Inflammatory Bowel Disease Genetics Consortium; Zhu S, Li D, Liu J, Ge T, Cho J, Daly MJ, McGovern DPB, Ye BD, Song K, Kakuta Y, Li M, Huang H. Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries. Nature Genetics. 2023 May;55(5):796-806. doi: 10.1038/s41588-023-01384-0. Epub 2023 May 8. PMID: 37156999; PMCID: PMC10290755. (IF=30.8)
59. Wang J, Zhao D, Lei Z, P Ge, Z Lu, Q Chai, Y Zhang, L Qiang, Y Yu, X Zhang, B Li, S Zhu, L Zhang#, C Liu#. TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal. Cell Mol Immunol 20, 158–174 (2023). https://doi.org/10.1038/s41423-022-00963-1. (IF=24.1)
2022
58. Zhang G*, Wang Q*, Tao W*, Jiang W, Elinav E, Wang Y#, Zhu S#. Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. Nature Biomedical Engineering. 2022 Jul;6(7):867-881. doi: 10.1038/s41551-022-00903-4. (IF=29.2)
57. Chen C*, W Zhang*, T Zhou, Q Liu, C Han, Z Huang, S Chen, Q Mei, C Zhang, K Zhang, H Ma, R Zhou, W Jiang, Wen Pan, Zhu S#. Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation. Cell Reports. 2022 Nov 29;41(9):111741. doi: 10.1016/j.celrep.2022.111741. (IF=10.0)
56. A Wang, W Tao, J Tong, J Gao, J Wang, G Hou, C Qian, G Zhang,R Li, D Wang, X Ren, K Zhang, S Ding, R Flavell, HB Li, W Pan#, S Zhu#.m6A modifications regulate intestinal immunity and rotavirus infection. Elife. 2022;11:e73628 DOI: https://doi.org/10.7554/eLife.73628 (IF=8.1)
55. Y Chen, X Wang, X Hao, B Li, W Tao, S Zhu, K Qu, H Wei, R Sun, H Peng, Z Tian. Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions. J Exp Med. 2022, 219(5): e20211805. (IF=17.58)
2021
54. Shen C*, Li R*, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S#, Wu H#. Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. 2021 Oct 14:S0092-8674(21)01115-6. doi:10.1016/j.cell.2021.09.032. (IF=41.6)
Comment in:
Cell Research. doi: 10.1038/s41422-021-00594-7. It’s just a phase: NLRP6 phase separations drive signaling.
53. M Guo*, W Tao*, R Flavell#, and S Zhu#. Potential intestinal infection and fecal–oral transmission of SARS-CoV-2. Nature Reviews Gastroenterology & Hepatology. 10.1038/s41575-021-00416-6 (IF=46.8)
52. Y Wang*, K He*, B Sheng*, X Lei, W Tao, X Zhu, Z Wei, R Fu, A Wang, S Bai, Z Zhang, N Hong, C Ye, Y Tian, J Wang, K Zhang, H Yang, L Li#, H Li#, R Flavell#, S Zhu#. The RNA helicase Dhx15 mediates Wnt-induced anti-microbial protein expression in Paneth cells. PNAS. 2021, 10.1073/pnas.2017432118 (IF=11.2)
51. Z Zhang*, G Zhang*, M Guo*, W Tao*, X Liu, H Wei, T Jin#, Y Zhang#, S Zhu#. The Potential Role of an Aberrant Mucosal Immune Response to SARS-CoV-2 in the Pathogenesis of IgA Nephropathy. Pathogens. 2021, 10(7), 881. doi: 10.3390/pathogens10070881(IF=3.5)
50. J Tong, X Wang, Y Liu, X Ren, A Wang, Z Chen, J Yao, K Mao, T Liu, F Meng, W Pan, Q Zou, J Liu, Y Zhou, Q Xia#, R Flavell#, S Zhu#, HB Li#. Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation. Science Advance. 10.1126/sciadv.abd4742 (IF=14.1)
49. Y Chen, S Zhao, J Hu, C Han, X Lv, G Wang, S Wang, P Bo, J Zhang, W Wu, W Gui, Q Tang#, Q Liu#, S Zhu#, F Yu#. Increased accumulation of α-Synuclein in inflamed appendix of Parkinson’s disease patients. Movement Disorders. 2021 Apr 20. doi: 10.1002/mds.28553 (IF=10.3)
48. X Zheng, L Liu, G Meng, S Zhu, R Zhou#, W Jiang#.IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner. Science Bulletin. Doi: 10.1016/j.scib.2021.01.025 (IF=11.8)
47. Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, Flavell RA, Zhu S, Li HB, Ding C, Wei H, Sun R, Peng H, Tian Z. METTL3-mediated m6A RNA methylation promotes the anti-tumor immunity of natural killer cells. Nat Commun. 2021 Sep 17;12(1):5522. doi: 10.1038/s41467-021-25803-0. (IF=14.9)
46. G Xu, C Liu, S Zhou, Q Li, Y Feng, P Sun, H Feng, Y Gao, J Zhu, X Luo, Q Zhan, S Liu, S Zhu, H Deng, D Li, P Gao. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. Molecular Cell. doi.org/10.1016/j.molcel.2021.05.002 (IF=18.0)
45. H Han, Y Cao, C Feng, Y Zheng, S Zhu, C Shang, C Yuan, G Zong. Association of a Healthy Lifestyle with All-Cause and Cause-Specific Mortality Among Individuals with Type 2 Diabetes: A Prospective Study in UK Biobank Short Running. Diabetes Care. doi.org/10.2337/dc21-1512 (IF=19.1)
2020
44. W Tao*, X Wang*, G Zhang*, M Guo, H Ma, D Zhao, L Liu, K Zhang, J Weng, Y Wang, X Ma#, T Jin# and S Zhu#. Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection.Protein & Cell. 10.1007/s13238-020-00778-8 (IF=10.2)
43. R Li, S Zhu#. 2019. NLRP6 Inflammasome. Mol Aspect Med. doi.org/10.1016/j.mam.2020.
100859 (IF=9.6)
42. W Tao*, G Zhang*, X Wang*, X Ma, T Jin, L Liu#, J Weng#, and S Zhu#. Analysis of the intestinal microbiota in COVID-19 patients and its correlation with the inflammatory factor IL-18. Medicine in Microecology. 10.1016/j.medmic.2020.100023
41. W Wen*, G Zhang*, S Luo*, Z Bai, W Tao, M Guo, S Jia, W Liu, K Zhang, J Weng#, S Zhu#. Next-generation sequencing revealed influenza and Chlamydia infection in recurrent pneumonia in a recovered COVID-19 patient. Precision Clinical Medicine. 10.1093/pcmedi/pbaa033
40. L Yang*, T Geng*, G Yang*, J Ma, L Wang, H Ketkhar, D Yang, T Lin, J Hwang, S Zhu, Y Wang, J Dai, F You, G Cheng, A Vella, R Flavell#, E Fikrig#, P Wang#. Macrophage scavenger receptor 1 controls Chikungunya virus 2 infection through autophagy in mice. Communications Biology. 3, 556. https://doi.org/10.1038/s42003-020-01285-6 (IF=4.2)
2019
39. L Liu*, T Gong*, W Tao*, B Lin, C Li, X Zheng, S Zhu#, W Jiang#, R Zhou#. 2019. Commensal viruses maintain the homeostasis of intestinal intraepithelial lymphocytes via non-canonical RIG-I signaling. Nat Immunol.10.1038/s41590-019-0513-z. (IF=21)
Comment in:
Nature Reviews immunology, 2019 Dec;19(12):721. Commensal viruses contribute to gut health.
38. H Ma*, W Tao*, and S Zhu#. 2019. T Lymphocytes in Intestinal Mucosa: Defense and Tolerance. Cell Mol Immunol. (2019) 16:216–224. (Invited review) (IF=9)
37. A Wang and S Zhu#. 2019. Gut Viruses Firm the “Great Wall”. Precision Clinical Medicine.doi.org/10.1093/pcmedi/pbz027.
36. W Zhang and S Zhu#. 2019. Gut metabolites: make orphans adopted. Precision Clinical Medicine.doi:10.1093/pcmedi/pbz012.
35. A Wang*, G Zhang*, W Tao*, S Zhu#. 2019. The immune response towards enteric virus in inflammatory bowel disease. 2019. Chin J Inflamm Bowel Dis. January 2019, Vol.3, No.1 (Invited review)
34. W Tao, S Zhu#. 2019. Gut virome in health and disease. Journal of Biology, 2019, 36(6): 1-. (Invited review)
33. J Wang, MF. Sanmamed, I Datar, T Su, L Ji, J Sun, L Chen, Y Chen, G Zhu, L Zheng, T Zhou, T Badri, S Yao, S Zhu, A Boto, M Sznol, I Melero, DA. Vignali, K Schalper and L Chen#. 2018. Fibrinogen-like protein 1 is a major ligand of LAG-3 for T-cell suppression and the evasion of tumor immunity. Cell. 176, 1–14.doi:org/10.1016/j.cell.2018.11.010. (IF=32)
2018
32. S Ding, S Zhu, L Ren, N Feng, X Ge, B Li, RA Flavell, HB Greenberg#. 2018. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. Elife. 2018 Nov 21;7. pii: e39494. doi: 10.7554/eLife.39494. (IF=8)
31. L Wu, J Cao, WL Cai, SM Lang, JR Horton, DJ Jansen, ZZ Liu, JF Chen, M Zhang, BT Mott, K Pohida, G Rai, SC Kales, MJ Henderson, X Hu, A Jadhav, DJ Maloney, A Simeonov, S Zhu, A Iwasaki, MD Hall, X Cheng, GS. Shadel, Q Yan#. 2018. KDM5 histone demethylases repress immune response via suppression of STING. Plos Biology. 2018 Aug 6;16(8):e2006134. doi: 10.1371/journal.pbio.2006134. (IF=9)
30. J Tong, G Cao, T Zhang, E Sefik, M Amezcua Vesely, J Broughton, S Zhu, H Li, B Li, Lei Chen, H Chang, B Su, R Flavell# & HB Li#. 2018. m6A mRNA methylation sustains Treg suppressive functions. Cell Research. doi:10.1038/cr.2018.7 (IF=15)
2017
29. Zhu S*, Ding S*, Wang P, Wang G, Lei X, Palm N, Pan W, Zheng Y, Feng N, Lu J, Shan L, Abraham C, Fikrig E, Greenberg H#, Flavell R#. Nlrp9b recognizes and restricts rotavirus infection in intestinal epithelial cells. 2017. Nature. doi:10.1038/nature22967. (IF=42)
Comment in:
Nature, doi:10.1038/nature23090; Gut sensor halts viral attack
Nat Rev Gastroenterol Hepatol. doi: 10.1038/nrgastro.2017.94. Rotavirus: Inflammasome modulates rotavirus infection;
Cell Research, doi: 10.1038/cr.2017.93, NLRP9b: a novel RNA-sensing inflammasome complex.
28. Li, H.*, J. Tong*, S. Zhu*, P. Batista, J.Zhao, W. Bailis, Y. Yang, G. Wang, Y. Chen, Y. Kluger, Howard Y. Chang, Zhinan Yin#, Richard A. Flavell#. 2017. m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway. Nature. doi:10.1038/nature23450. (IF=42)
27. Pan W, Zhu S, K Qu, K Meeth, J Cheng, K He, H Ma, Y Liao, X Wen, C Roden, Z Tobiasova, Z Wei, J Zhao, J Liu, J Zheng, B Guo, M Bosenberg, R Flavell, J Lu#. 2017. Tet2 sustains the immunosuppressive function of myeloid cells and promotes melanoma growth. Immunity. 2017, doi: 10.1016/j.immuni.2017.07.020. (IF=24)
26. Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA#. 2017. A novel humanized mouse model with significant improvement of class- switched, antigen-specific antibody production. Blood. doi: 10.1182/blood-2016-04-709584. (IF=12)
25. H Yu, N Gagliani, H Ishigame, S Huber, S Zhu, E Esplugues, K Herold, L Wen, R Flavell#. 2017. Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development. Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1705599114. (IF=10)
2016
24. Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA#. 2016. The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury. Science. 2016 Nov 11;354(6313):765-768. (IF=41)
23. Shu Zhu, Geng Wang, Xuqiu Lei, Richard A. Flavell#. 2016. Mex3B, a coreceptor to present dsRNA to TLR3. Cell Research. 26(4):391-2. doi: 10.1038/cr.2016.29. (IF=15)
22. Cheng J, Roden CA, Pan W, Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman SM, Guo S, Flavell RA, Ding Y, Lu J#. 2016. A Molecular Chipper Technology for CRISPR sgRNA Library Generation and Functional Mapping of Noncoding Regions. Nature Communication. 7:11178. doi: 10.1038/ncomms11178. (IF=12)
2015
21. Wang P*, Zhu S*, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R#, Fikrig E#. Nlrp6 regulates intestinal antiviral innate immunity. Science. 2015 Nov 13;350(6262):826-30. doi: 10.1126/science.aab3145. (IF=41)
Comment in:
Science Signaling (2015) DOI: 10.1126/scisignal.aad8628; Nlrp6 keeps gut infections in check
20. Pan W*, Zhu S*, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y,.. Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley J, Flavell R, Yao Y# and Shen N#. 2015. MiR-125a targets effector programs to stabilize Treg mediated immune homeostasis and controls autoimmunity. Nature Communications. DOI: 10.1038/ncomms8096. (*co-first author) (IF=12)
19. Song X, Dai D, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N, Qian Y#. 2015. Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity. doi:10.1016/j.immuni.2015.06.024. (IF=24)
18. W Pan, S Zhu, D Dai, J Harley, N Shen#. 2015. T cell transfer Model of Colitis. Bio-protocol. 10.21769/BioProtoc.1862
2014
17. Zhu S, Li HB, Flavell RA#. 2014. Resemble and Inhibit: when RLR meets TGF-b. Molecular Cell. Dec 18;56(6):719-20. doi:10.1016/j.molcel.2014.12.010. (IF=14)
16. Zhu S, Jackson R, Flavell RA#. 2014. The lock-washer: a reconciliation of the RIG-I activation models. Cell Research.10.1038/cr.2014.5. (IF=15)
15. Marcel R. de Zoete*, Noah W. Palm*, Shu Zhu*, Richard A. Flavell#. 2014. Inflammasomes. Cold Spring Haber Perspectives in Biology. Oct 16;6(12):a016287. doi: 10.1101/cshperspect.a016287 (*co-first author) (IF=12)
14. Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y#. 2014. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity. 40 (1), 140-152. (IF=24)
13. W Pan, S Zhu, D Dai, J Harley, N Shen#. 2014. Mir-125a Is Critical Regulator for Controlling Autoimmunity in Multiple Autoimmune Diseases through Stabilizing Treg Mediated Immune Homeostasis.Arthritis & Rheumatology.66():S1245, OCT 2014. (IF=8)
2013
12. Zhu S#, Pan W, Qian Y#. 2013. MicroRNA in immunity and autoimmunity. J Mol Med. Sep;91(9):1039-50. doi: 10.1007/s00109-013-1043-z. (#co-corresponding author; Invited review) (IF=5)
11. Cao J, Zhu S, Zhou W, Li J, Liu C, Xuan H, Yan J, Zheng L, Zhou L, Yu J, Chen G, Huang Y, Yu Z, Feng L#. 2013. PLZF Mediates the PTEN/AKT/FOXO3a Signaling in Suppression of Prostate Tumorigenesis. PLoS One. 8 (12), e77922. (IF=4)
2012
10. Zhu, S.*, W. Pan*, X. Song, Y. Liu, Y. Tang, H. Wang, W. Liu, Y. Shi, D. He, J.B. Harley, N. Shen and Y. Qian#. 2012. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nature Medicine. 18: 1077-1086. DOI 10.1038/nm.2815. (IF=33)
Comment in:
Nature Medicine (2012) 18, 1009–1010; MiR-23b is a safeguard against autoimmunity.
9. Zhu, S. & Qian, Y#. 2012. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clin Sci (Lond) 122, 487-511. (Invited review) (IF=5)
8. Yao Y., Y. Wang, F. Chen, Y. Huang, S. Zhu, Q. Leng, H. Wang, Y. Shi, Y. Qian#. 2012. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogen. Cell Research. 04/2012; (IF=15
7. Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y#. 2012. TRAF6-Dependent Act1 Phosphorylation by the I kappa B Kinase-Related Kinases Suppresses Interleukin-17-Induced NF-kappa B Activation. Mol Cell Biol 32: 3925-3937. (IF=4)
2011
6. Song, X., S. Zhu, P. Shi, Y. Liu, Y. Shi, S.D. Levin, and Y. Qian#. 2011. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nature Immunology. 12:1151-8. (IF=22)
5. Shi, P., S. Zhu, Y. Lin, Y. Liu, Z. Chen, Y. Shi, and Y. Qian#. 2011. Persistent stimulation with interleukin-17 desensitizes cells through SCFbeta-TrCP-mediated degradation of Act1. Science Signaling. 4:ra73. (IF=7)
4. Shi P, Zhu S and Y Qian#. 2011. IL-17 mediated signaling and function. Chin J Cell Bio. 2011, 33(4): 345-357. (Invited review)
2010
3. Zhu, S., W. Pan, P. Shi, H. Gao, F. Zhao, X. Song, Y. Liu, L. Zhao, X. Li, Y. Shi, and Y. Qian#. 2010. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med. 207:2647-2662. (IF=15)
Research highlight in:
Nature Medicine (2011) 17:52; Immunology: Taming IL-17 inflammation
Nature Immunology (2011) 12:19; TRAF3 suppresses IL-17R
2. Pan, W*, S. Zhu*, M. Yuan, H. Cui, L. Wang, X. Luo, J. Li, H. Zhou, Y. Tang, and N. Shen#. 2010. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol. 184:6773-6781. (*co-first author; 331 citations) (IF=5)
2009
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招生招聘：
实验室长期招收对研究肠道免疫与微生物相互作用感兴趣的博士后、博士研究生、以及本科实习生，实验室注重多背景交叉融合，专业方向不限。