张华凤，中国科学技术大学 教授 博士生导师，国家基金委杰出青年基金获得者，主要从事肿瘤微环境与肿瘤细胞代谢、肿瘤转移的调控机制以及抗肿瘤药物的研发等，尤其关注肿瘤细胞与微环境免疫细胞间如何通过代谢发生相互调控，导致肿瘤细胞免疫逃逸的相关机制研究，并基于此开发抗肿瘤治疗的新策略。担任安徽省生物工程学会副理事长、中国抗癌协会肿瘤代谢专业委员会常委、中国细胞生物学学会细胞信号转导分会委员、安徽省药学会精准药物治疗专委会常委及副主委等。

主要研究兴趣:

1. 肿瘤免疫与肿瘤代谢

2. 肿瘤转移的分子机制研究

3. 新型抗肿瘤药物的筛选和研发

近期代表性论文(*通讯作者)

1. Hao Y^#, Zhou Z^#, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li ST, Liu Z, Chu Y, Sun L*, Gao P*, Zhang H*. Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance. Nature Chemical Biology 2025 Jun;21(6):926-938.

2. Ma W^#, Sun Y^#, Yan R, Zhang P, Shen S, Lu H, Zhou Z, Jiang Z, Ye L, Mao Q, Xiong N, Jia W, Sun L, Gao P*, Zhang H*. OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB. Molecular Cell2024 Feb 1;84(3):538-551.

3. Wei H, Suo C, Gu X, Shen S, Lin K, Zhu C, Yan K, Bian Z, Chen L, Zhang T, Yan R, Yang Z, Yu Y, Li Z, Liu R, He J, He Q, Zhong X, Jia W, Wong CM, Dong Z, Cao J, Sun L, Zhang H*, Gao P*. AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity. Cell Metabolism 2025 May 6;37(5):1103-1118.

4. Yan R^#, Zhang P^#, Shen S, Zeng Y, Wang T, Chen Z, Ma W, Feng J, Suo C, Zhang T, Wei H, Jiang Z, Chen R, Li ST, Zhong X, Jia W, Sun L, Cang C, Zhang H*, Gao P*. Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion. Nature Immunology 2024 Mar;25(3):483-495.

5. Wang T^#, Zhou Y^#, Zhou Z, Zhang P, Yan R, Sun L, Ma W, Zhang T, Shen S, Liu H, Lu H, Ye L, Feng J, Chen Z, Zhong X, Wu G, Cai Y, Jia W, Gao P*, Zhang H*. Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps. Nature Communications 2023 Mar 18;14(1):1513.

联系方式：

电话：63607012；办公室电话：63607131

E-mail: hzhang22@ustc.edu.cn