教授 博士生导师 1997年至2007年间就读于中国科学技术大学并获得细胞生物学博士学位 后赴美国宾夕法尼亚大学继续进行博士后研究工作, 于2013年归国后，加入中国科学技术大学担任教授，博士生导师。在求学及从事研究工作期间，在《Science》，《Signal Transduction and Targeted Therapy》，《Journal of Cell Biology》，《Molecular Cell》，《Cell reports》，《Chemical Communications》等世界顶级及领域内著名杂志上发表多篇研究论文，研究成果得到同行专家的广泛认可。

主要研究兴趣：

1.  生物大分子相分离与蛋白质翻译后修饰的调控网络研究；

2.  生物大分子相分离的生物学功能鉴定及与疾病的相关性研究；

3.  基于生物大分子相分离的疾病相关药物的发现及优化。

发表文章：

1. Feng Chen^#;Siyuan Shen^#;Xu Cao;Liang Zhang;Lunxu Liu;Daoke Yang;Yunyu Shi;Wei H*e;XuebiaoYao*;Dan Liu*;Predicting assembly mode of membraneless organelles by a FRET based crowding sensor，Signal Transduction and Targeted Therapy.（Accepted）

2. Sun Xuan^#;Chen Feng;Zhang Lili;Liu Dan*;A gene-encoded FRET fluorescent sensor designed for detecting asymmetric dimethylation levels in vitro and in living cells,Analytical and Bioanalytical Chemistry,2023,415:1411–1420

3. Wang, DJ^#; Ge, YS^# *; Zhong, B; Liu, D*; Specific epitopes form extensive hydrogen-bonding networks to ensure efficient antibody binding of SARS-CoV-2: Implications for advanced antibody design, Computational and Structural Biotechnology Journal, 2021, 19: 1661-1671.

4. Duan, WX^#; Huang, FY^#; Bi, YH; Zhu, LL; Wang, DJ; Liu, Y; Wu, J*; Ge, YS*; Liu, D*; Design, synthesis and cell imaging of a simple peptide-based probe for the selective detection of RNA, Chemical Communications, 2021, 57: 2653-2656.

5. Bi, YH; Duan, WX; Chen, J; You, T; Li, SY; Jiang, W; Li, M; Wang, G; Pan, XY; Wu, J; Liu, D; Li, J*; Wang, YC*. Neutrophil Decoys with Anti-Inflammatory and Anti-Oxidative Properties Reduce Secondary Spinal Cord Injury and Improve Neurological Functional Recovery. Advanced Functional Materials. 2021,31: 202102912.

6. Xu, L; Ali, M; Duan, WX; Yuan, X*; Garba, F; Mullen, M; Sun, B; Poser, I; Duan, HQ;  Lu, L; Tian, RJ; Ge, YS; Chu, LL; Pan, WJ; Wang, DM; Hyman, A; Green, H; Li, L; Dou, Z; Liu, D*; Liu, X*; Yao,XB*. Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation. Cell Reports, 2021, 36:109343.

7. Han, QQ; Chen, F; Liu, SS; Ge, YS*; Wu, J*; Liu, D*; Genetically encoded FRET fluorescent sensor designed for detecting MOF histone acetyltransferase activity in vitro and in living cells, Analytical and Bioanalytical Chemistry, 2021,413: 5453-5461.

8. Lu, H^#; Zhu, LL^#; Li, WQ; Hu, SY; Ge, YS*; Liu, D*; Novel gene-encoded intermolecular FRET sensor for tracking glycosylation of CD147 in living cells, Analytical and Bioanalytical Chemistry, 2021, 413(12): 3193-3199.

9. Chen, K; Duan, WX; Han, QQ; Sun, X; Li, WQ; Hu, SY; Wan, JJ; Wu, J; Ge, YS*; Liu, D*; Identification of the hot spot residues for pyridine derivative inhibitor CCT251455 and ATP substrate binding on monopolar spindle 1 (MPS1) kinase by molecular dynamic simulation, Journal of Biomolecular Structure and Dynamics, 2019, 37: 611-622.

10. Wan, JJ^#; Duan, WX^#; Chen, K; Tao, YD; Dang, J; Zeng, KH; Ge, YS*; Wu, J*; Liu, D*; Selective and sensitive detection of Zn(II) ion using a simplepeptide-based sensor, Sensors and Actuators B, 2018, 255: 49-56.

11. Ge, YS; Han, QQ; Duan, WX; Zhang, JQ; Chen, K; Wan, JJ; Liu, Y*; Liu, D*; Discovery of Cdc25A Lead Inhibitors with a Novel Chemotype by Virtual Screening: Application of Pharmacophore Modeling Based on a Training Set with a Limited Number of Unique Components, ChemMedChem, 2017, 12: 438-447.

12. Yang, JC^#; Rong, H^#; Shao, P; Tao, YD; Dang, J; Wang, P; Ge, YS*; Wu, J*; Liu, D*; Highly selective ratiometric peptide-based chemosensors for zinc ions and applications in living cell imaging: a study for reasonable structure design, Journal of Material Chemistry B, 2016, 4: 6065-6073.

13. Liu, D; Vader, G; Vromans, MJ; Lampson, MA*; Lens, SM. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science. 2009 Mar; 323:1350-1353.

14. Liu, D; Davydenko, O; Lampson, MA*; Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing. Journal of Cell Biology. 2012 Aug; 198:491-499.

15. Welburn, JP; Vleugel, M; Liu, D; Yates, III JR; Lampson, MA; Fukagawa, T; Cheeseman, IM*. Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface. Molecular Cell. 2010 May; 38:383-392.

16. Liu, D; Vleugel, M; Backer, CB; Hori, T; Fukagawa, T; Cheeseman, IM; Lampson, MA*. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. Journal of Cell Biology. 2010 March; 188:809-820.

17. Liu D; Vader G. ; Vromans M.J. ; Lampson M.A. ; Lens S.M; Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science. 2009 Mar; 323:1350-1353.

18. Liu D. ; Zhang N. ; Du J. ; Cai X. ; Zhu M. ; Jin C. ; Dou Z. ; Feng C. ;  Yang Y. ;  Liu L. ; Takeyasu K. ; Xie W.;Yao X;2006. Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis. Biochem Biophys Res Commun. 2006 Apr; 345:394-402.

19. Xue Y. ^#;Liu D. ^#; Fu C.;Dou Z.; Zhou Q.;Yao X. A novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins. Chinese Science Bulletin. 2006 Aug; 51:1836-1847. († equal contribution)

联系方式：
电话：0551-63601619
电子邮件: dliu919@ustc.edu.cn