曹洋，特任教授，博士生导师，入选国家海外高层次人才计划。2015年博士毕业于中国科学技术大学，2015年至2023年先后在美国华盛顿大学、耶鲁大学和加州大学洛杉矶分校任博士后和助理研究员。2023年4月加入中国科学技术大学生命科学与医学部，组建心血管代谢实验室。主要研究方向为心血管代谢疾病，包括心力衰竭、肥胖、糖尿病等，采用系统遗传学和分子生物学方法探究心血管代谢疾病的病理生理机制。主要工作发表于Science，Circulation，Circulation Research （2017，2024）, Nature Communications, EMBO Journal等期刊上，研究成果被Science，Nature Reviews Cardiology，Circulation, Circulation Research, Cardiovascular Research等期刊关注和报道。
主要研究兴趣：
利用人和鼠的多组学数据库研究心血管代谢疾病。利用约100种不同基因背景的近交品系HMDP（Hybrid Mouse Diversity Panel）小鼠构建心血管代谢疾病模型以模拟不同病人的群体多样性，结合系统遗传学、分子生物学和细胞生物学来探究心血管代谢疾病的遗传基础和病理机制。
1. 器官间相互作用对心力衰竭发生发展的影响
2. 心脏舒张功能调控的遗传机制
3. 肝脏代谢和肠道微生物对心脏功能的调控
4. 线粒体功能在心血管代谢疾病中的作用
课题组招聘：
课题组招聘对细胞生物学、分子生物学、心血管和代谢等方向感兴趣的博士后、特任副研究员和研究生。简历发送至yangcao208@ustc.edu.cn。
（1）特任副研究员和博士后：具有细胞分子生物学、生物信息学、心血管代谢等相关背景的已博士毕业或即将博士毕业的科研人员。
（2）研究生：诚挚欢迎对本课题组感兴趣的同学加入课题组，攻读学位。
代表论文：
Cao Y, Wang Y-C, Zhou Z, Pan C, Jiang L, Zhou Z, Meng Y, Charugundla S, Li T, Allayee H, Seldin MM, and Lusis AJ. Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure. Science (IF=63.7).2022;377(6613):1399-1406. PubMed PMID: 36137043.
Comment in “A coagulation factor moonlights in the heart”. Tong D, Hill JA. Science. 2022 Sep 23;377(6613):1382-1383.
Comment in “Liver-derived factor XI protects against HFpEF.” Huynh K. Nat Rev Cardiol. 2022 Dec;19(12):781. doi: 10.1038/s41569-022-00800-y.
Comment in “The unknown functions of a known protein: the case of coagulation factor XI”. van der Vorst EPC, Badimon L. Cardiovasc Res. 2023 Jul 4;119(7):e137-e139. doi: 10.1093/cvr/cvad066.
Cao Y, Pan C, Wang Y-C, Zhou Z, Jedian V, Meng Y, Campbell G, Guardino K, Li C, Wang J, and Lusis AJ. Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure with Preserved Ejection Fraction (HFpEF). Circulation (IF=39.9). 2022 Apr 5;145(14):1102-1104.
Wang YC, Koay YC, Pan C, Zhou Z, Wilson Tang WH, Wilcox J, Li XS, Zagouras A, Marques F, Allayee H, Rey FE, Kaye DM, O'Sullivan JF, Hazen SL, Cao Y*, and Lusis AJ*. Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction. Circulation Research (IF=23.21). 2024 Feb 16. PubMed PMID: 38264909. (Featured article, *co-corresponding author)
Comment in “From Gut to Heart: Role of Indole-3-Propionic Acid in HFpEF”. Vacca A, Schiattarella GG. Circ Res. 2024 Feb 16;134(4):390-392. PubMed PMID: 38359099.
Cao Y, Vergnes L, Wang Y-C, Pan C, Krishnan KC, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Vondriska TM, Wang Y, Reue K, and Lusis AJ. Sex Differences in Heart Mitochondria Regulate Diastolic Dysfunction. Nat Commun (IF=17.7). 13, 3850 (2022).
Comment in “Unexplored horizons on sex bias and progression of heart failure with preserved ejection fraction”. Benincasa G, Napoli C. Eur Heart J Cardiovasc Pharmacother. 2023 Sep 20;9(6):502-504. doi: 10.1093/ehjcvp/pvad050.
Cao Y#, Bojjireddy N#, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD, Tian R. Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury. Circulation Research (IF=23.21). 2017 Oct 27;121(10):1182-1191. (#co-first author)
Cao Y#, Guo WT#, Tian S, He X, Wang XW, Liu X, Gu KL, Ma X, Huang D, Hu L, Cai Y, Zhang H, Wang Y, Gao P. miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency. EMBO J. (IF=14.01). 2015 Mar 4;34(5):609-23. doi: 10.15252/embj.201490441. Epub 2015 Jan 20. (#co-first author)
Cao Y*, Lusis AJ, Coagulation factor with potential for the treatment of heart failure. Clin Transl Med (IF=10.6). 2022; 00: e1144. (*corresponding author)
Cao Y#, Aquino-Martinez R#, Hutchison E#, Allayee H, Lusis AJ*, and Rey FE. Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach. Mol Metab. (IF=8.57). 2022 Jul 20:101557. doi: 10.1016/j.molmet.2022.101557. (#co-first author, *corresponding author)
Wang YC, Cao Y, Pan C, Zhou ZQ, Yang LL, Lusis AJ. Heterogeneity of small intestinal immune and epithelial cells and their cellular response network to a western diet. J Exp Med (IF=17.58). 2023. (2023) 220 (5): e20221437.
Li T, Zhang Z, Kolwicz SC Jr, Abell L, Roe ND, Kim M, Zhou B, Cao Y, Ritterhoff J, Gu H, Raftery D, Sun H, Tian R. Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury. Cell Metabolism (IF=27.28). 2017 Feb 7;25(2):374-385. doi: 10.1016/j.cmet.2016.11.005.
Moore T, Cheng L, Wolf D, Ngo J, Segawa M, Zhu X, Strumwasser A, Cao Y, Clifford B, Ma A, Scumpia P, Shirihai O, Vallim T, Laakso M, Lusis AJ, Hevener A, Zhenqi Zhou. Parkin Regulates Adiposity by Coordinating Mitophagy with Mitochondrial Biogenesis in White Adipocytes. Nat Commun. (IF=17.7).2022;13(1):6661. Published 2022 Nov 4.
Lee CF, Cao Y, Tian R. Failed Power Plant Turns into Mass Murder: New Insight on Mitochondrial Cardiomyopathy. Circulation Research (IF=23.21). 2018 Jan 5;122(1):11-13. doi: 10.1161/CIRCRESAHA.117.312288.
Krishnan KC, Hachem EJ, Keller MP, Patel SG, Carroll L, Vegas AD, Gyuricza IG, Light C, Cao Y, Pan C, Kaczor-Urbanowicz KE, Shravah V, Anum D, Pellegrini M, Lee CF, Seldin MM, Rosenthal NA, Churchill GA, Attie AD, Parker BL, James DE, and Lusis AJ. Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy. Elife (IF=7.7). 2023 Jun 5;12:e82619. doi: 10.7554/eLife.82619.
联系方式：
办公室：生物楼主楼726
邮箱：yangcao208@ustc.edu.cn