个人简介：
博士，双聘特任研究员。中国科学院优秀博士论文获得者、安徽省学术和技术带头人后备人选、安徽省自然科学一等奖获得者（2/4）。中国科学技术大学生物化学与分子生物学博士。主要从事非编码RNA在肿瘤及心血管病等重大疾病中功能与功能机理方面的研究。历任中国科大生医部基础医学院博士后、特任副研究员，2023年4月起双聘于中国科学技术大学生命科学与医学部和附属第一医院心血管病研究所工作。期间获得并主持国家自然科学基金面上项目与青年项目；安徽省自然科学基金、安徽省高校杰出青年科研项目、国家博士后科学基金、校青年创新基金等项目，并作为课题骨干参与科技部国家重大研发计划。主要研究成果发表在Nature Communications、PNAS、Trends in Biochemical Sciences、Oncogene、Genome Research、Cancer Letters等期刊。曾获中国科大生命科学学院第一届“杰出论文研究奖”。现任安徽省病理生理学会心血管分会常委、安徽省抗癌学会家族遗传性肿瘤分会常委。
主要研究兴趣：
1、非编码RNA（如环状RNA、长链非编码RNA等）在肿瘤与心血管病中的功能与机理
2、非编码RNA参与肿瘤转移、耐药调控的分子机制及药物筛选
3、非编码RNA与外部应激调控
4、环状RNA生成、出核调控的生理病理关联
代表性论著（第一/通讯）：
(1) Yinchun Zhong#, Yan Yang#, Xiaolin Wang, Bingbing Ren, Xueren Wang*, Ge Shan*, Liang Chen*, Systematic identification and characterization of Exon-intron circRNAs, Genome Research, 2024, 34(3):376-393.
(2) Hanyuan Liu, Sisi Deng, Xuelin Yao, Yi Liu, Lili Qian, Yingying Wang, Tianjiao Zhang, Ge Shan*, Liang Chen*, Ying Zhou*, Ascites exosomal lncRNA PLADE enhances platinum sensitivity by inducing R-loops in ovarian cancer, Oncogene, 2024, 43(10):714-728.
(3) Gui-Bin Gao#, Liang Chen#, Jia-Feng Pan, Tao Lei, Xin Cai, Zhexue Hao, Qi Wang, Ge Shan, Jin Li*, LncRNA RGMB-AS1 inhibits HMOX1 ubiquitination and NAA10 activation to induce ferroptosis in non-small cell lung cancer, Cancer Letters, 2024, 216826.
(4) Shuhui Chang#, Yucong Wang#, Xiaolin Wang, Hanyuan Liu, Tao Zhang, Yangge Zheng, Xueren Wang, Ge Shan*, Liang Chen*, HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes, RNA Biology, 2024, 21(1):1-15.
(5) Xu Liu#, Xuelin Yao#, Liang Chen*, Expanding roles of circRNAs in cardiovascular disease, Non-coding RNA Research, 2024, 9(2):429-436
(6) Xuelin Yao#, Hanyuan Liu#, Zhen Wang, Fangting Lu, Wenying Chen, Qing Feng, Yahu Miao, Jie Zhang, Yanlei Wang, Ye Chen, Liping Xue, Yehai Liu, Liang Chen*, Qiu Zhang*, Circular RNA EIF3I promotes papillary thyroid cancer progression by interacting with AUF1 to increase Cyclin D1 production, Oncogene, 2023, 42(43):3206-3218.
(7) Sisi Deng; Lili Qian; Luwen Liu; Hanyuan Liu; Zhihao Xu; Yujie Liu; Yingying Wang; Liang Chen*; Ying Zhou*; Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1, Cancer Science, 2023, 114(4):1582-1595
(8) Liang Chen#; Yucong Wang#; Jiamei Lin; Zhenxing Song; Qinwei Wang; Wenfang Zhao; Yan Wang; Xiaoyu Xiu; Yuqi Deng; Xiuzhi Li; Qiqi Li; Xiaolin Wang; Jingxin Li; Xu Liu; Kunpeng Liu; Jincong Zhou; Kuan Li; Yuchan Liu; Shanhui Liao; Qin Deng; Chao Xu; Qianwen Sun; Shengzhou Wu; Kaiming Zhang; Min-Xin Guan; Tianhua Zhou; Fei Sun; Xiujun Cai; Chuan Huang*; Ge Shan*; Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs, Nature Communications, 2022, 13(1): 5769
(9) Liang Chen, Chuan Huang*, Ge Shan*; Circular RNAs in physiology and non-immunological diseases, Trends in Biochemical Sciences, 2022, 47(3): 250-264
(10) Pengcheng Liu#; Yucong Wang#; Ningning Zhang; Xiaomin Zhao; Renming Li; Yu Wang; Chen Chen; Dandan Wang; Xiaoming Zhang; Liang Chen*; Dahai Zhao*; Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease., Respiratory Research, 2022, 23(1): 154-154
(11) Liang Chen*, Ge Shan*, CircRNA in cancer: Fundamental mechanism and clinical potential, Cancer Letters, 2021,18;505:49-57.
(12) Hanyuan Liu, Chenchen Zhu, Zhihao Xu, Juan Wang, Lili Qian, Qingqing Zhou, Zhen Shen, Weidong Zhao, Weihua Xiao, Liang Chen*, Ying Zhou*; lncRNA PART1 and MIR17HG as δNp63 alpha direct targets regulate tumor progression of cervical squamous cell carcinoma, Cancer Science, 2020, 111(11): 4129-4141
(13) Ying Zhou#; Hanyuan Liu#; Juan Wang; Xiaolin Wang; Lili Qian; Fei Xu; Weiguo Song; Dabao Wu; Zhen Shen; Dingqing Feng; Bin Ling; Weihua Xiao; Ge Shan*; Liang Chen*; ΔNp63α exerts antitumor functions in cervical squamous cell carcinoma, Oncogene, 2019, 39: 905-921
(14) Zhiyong Sheng, Xiaolin Wang, Geliang Xu*, Ge Shan*, Liang Chen*, Analyses of a panel of transcripts identified from a small sample size and construction of RNA networks in hepatocellular carcinoma, Frontiers in Genetics, 2019, 10:431.
(15) Liang Chen*, Emmanuel Enoch Dzakah, Ge Shan*, Targetable long non-coding RNAs in cancer treatments, Cancer Letters, 2018, 418, 119–124.
(16) Hassaan M Awan#, Abdullah Shah#, Farooq Rashid#, Shuai Wei, Liang Chen*, Ge Shan*, Comparing two approaches of miR-34a target identification, biotinylated-miRNA pulldown vs miRNA overexpression. RNA Biology, 2018(15): 55-61.
(17) Abdullah Shah#, Farooq Rashid#, Hassaan M Awan#, Shanshan Hu, Xiaolin Wang, Liang Chen*, Ge Shan*, The DEAD-Box RNA Helicase DDX3 Interacts with m(6)A RNA Demethylase ALKBH5. Stem Cells International, 2017, 10.1155/ 2017/ 8596135.
(18) Liang Chen, Farooq Rashid, Abdullah Shah, Hassaan M Awan, Mingming Wu, An Liu, Jun Wang, Tao Zhu, Zhaofeng Luo, Ge Shan*, The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation, Proceedings of National Academy of Sciences U S A (PNAS), 2015, 112(32):10002-10007.
(19) Liang Chen, Ge Shan*, Circular RNAs remain peculiarly unclear in biogenesis and function, Science China Life Sciences, 2015, 58(6):616-618.
(20) Liang Chen, Chuan Huang, Xiaolin Wang, Ge Shan*, Circular RNAs in Eukaryotic Cells, Current Genomics, 2015, 16(5) :312-318.
联系方式：
办公室：0551-63601356
E-mail: anqingcl@ustc.edu.cn