陈 亮

陈 亮


陈亮,博士,特任副研究员。博士毕业于中国科学技术大学生物化学与分子生物学专业,获理学博士学位。随后在中国科学技术大学生命科学学院进行博士后研究,期间获得并主持国家自然科学基金青年基金项目、国家博士后科学基金、安徽省自然科学基金青年项目、中国科学技术大学青年创新基金,作为课题骨干参与国家重大研发计划子课题。20178月起任中国科学技术大学生命科学学院副研究员,从事非编码RNA功能与功能机理方面的研究。主要研究成果发表在P.N.A.S2015, Direct submission, cited in Nature Reviews Drug Discovery, 2017 as a key reference with highlight about the significance of this work),Nature Structural & Molecular Biology2015, Highlighted in Nature Reviews Molecular Cell Biology Science Editors’ Choice, Oncogene, Cancer Letters等期刊。曾获安徽省自然科学一等奖(第二完成人)、中国科学院优秀博士论文(即中科院“百篇优博”,2016)、中国科学技术大学生命科学学院第一届“杰出论文研究奖”(2016)。同时担任Frontiers in Molecular Biosciences杂志客座副编辑。

 

主要研究兴趣:

1、非编码RNA功能与功能机理

2、非编码RNA与疾病

 

代表性论文:

(1) Liang Chen*, Ge Shan*, CircRNA in cancer: Fundamental mechanism and clinical potential, Cancer Letters, 2021,18;505:49-57.

(2) Hanyuan Liu# , Chenchen Zhu# , Zhihao Xu, Juan Wang, Lili Qian, Qingqing Zhou, Zhen Shen, Weidong Zhao, Weihua Xiao, Liang Chen*, Ying Zhou*, lncRNA PART1 and MIR17HG as ΔNp63α direct targets regulate tumor progression of cervical squamous cell carcinoma, Cancer Science, 2020, 111(11):4129-4141.

(3) Ying Zhou#, Hanyuan Liu#, Juan Wang, Xiaolin Wang, Lili Qian, Fei Xu, Weiguo. Song, Dabao Wu, Zhen Shen, Dingqing Feng, Bing Ling, Weihua Xiao, Ge Shan*, Liang Chen*. DeltaNp63alpha exerts antitumor functions in cervical squamous cell carcinoma. Oncogene 2019, 39(4):905-921.

(4) Zhiyong Sheng, Xiaolin Wang, Geliang Xu*, Ge Shan*, Liang Chen*, Analyses of a panel of transcripts identified from a small sample size and construction of RNA networks in hepatocellular carcinoma, Frontiers in Genetics, 2019, 10:431.

(5) Liang Chen*, Emmanuel Enoch Dzakah, Ge Shan*, Targetable long non-coding RNAs in cancer treatments, Cancer Letters, 2018, 418, 119–124.

(6) Hassaan M Awan#, Abdullah Shah# , Farooq Rashid#, Shuai Wei, Liang Chen*, Ge Shan*, Comparing two approaches of miR-34a target identification, biotinylated-miRNA pulldown vs miRNA overexpression. RNA Biology, 2018(15): 55-61.

(7) Abdullah Shah#, Farooq Rashid#, Hassaan M Awan#, Shanshan Hu, Xiaolin Wang, Liang Chen*, Ge Shan*, The DEAD-Box RNA Helicase DDX3 Interacts with m(6)A RNA Demethylase ALKBH5. Stem Cells International, 2017, 10.1155/ 2017/ 8596135.

(8) Liang Chen, Ge Shan*, Circular RNAs remain peculiarly unclear in biogenesis and functionScience China Life Sciences, 2015, 58(6):616-618.

(9) Liang Chen, Farooq Rashid, Abdullah Shah, Hassaan M Awan, Mingming Wu, An Liu, Jun Wang, Tao Zhu, Zhaofeng Luo, Ge Shan*The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutationProceedings of National Academy of Sciences U S A, 2015, 112(32):10002-10007.

(10) Zhaoyong Li#, Chuan Huang#, Chun Bao#, Liang Chen, Mei Lin, Xiaolin Wang, Guolin Zhong, Bin Yu, Wanchen Hu, Limin Dai, Pengfei Zhu, Zhaoxia Chang, Qingfa Wu, Yi Zhao, Ya Jia, Ping Xu, Huijie Liu, Ge Shan*, Exon-intron circular RNAs regulate transcription in the nucleusNature Structural & Molecular Biology2015,22(3):256-264.

 

联系方式:

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